Opening book details…
Can I read Direct Infusion-Three-Dimensional-Mass Spectrometry Enables Rapid Chemome Comparison among Herbal Medicines on EtoBox?
Direct Infusion-Three-Dimensional-Mass Spectrometry Enables Rapid Chemome Comparison among Herbal Medicines by Xia Xu; Wei Li; Ting Li; Ke Zhang; Qingqing Song; Li Liu; Pengfei Tu; Yitao Wang; Yuelin Song; Jun Li is a Chemistry article available to read on EtoBox.
What is Direct Infusion-Three-Dimensional-Mass Spectrometry Enables Rapid Chemome Comparison among Herbal Medicines about?
Direct infusion-mass spectrometry (DI-MS) currently serves as an alternative analytical tool for metabolomics owing to the unique high-throughput advantage. Except the inherent shortcoming at a significant matrix effect, there are two other primary technical obstacles dampening its wide applications, such as data alignment and structural annotation. To address these two obstacles, a novel strategy termed as DI-three-dimensional-MS (DI-3D-MS) was proposed here, and chemome comparison among several confusing herbal medicines (HMs) belonging to the family was conducted as a proof-of-concept. Each test sample was directly infused into Qtrap-MS. In the first dimension, stepwise multiple ion monitoring (MIM) program was implemented to universally acquire the quantitative information on all HMs and to generate aligned data files. In the second dimension, MS spectra were universally recorded by enhanced product ion (EPI) experiments that were triggered by MIM via an information-dependent acquisition algorithm. In the third dimension, online energy-resolved MS (ER-MS) was programmed to yield breakdown graphs for all MIM items. Moreover, a data library was built to aid structural identificat
Who reads Direct Infusion-Three-Dimensional-Mass Spectrometry Enables Rapid Chemome Comparison among Herbal Medicines?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Xia Xu; Wei Li; Ting Li; Ke Zhang; Qingqing Song; Li Liu; Pengfei Tu; Yitao Wang; Yuelin Song; Jun Li
- Publisher
- American Chemical Society; American Chemical Society (ACS) (ISSN 0003-2700)
- Published
- 2020
- Language
- EN
- Field
- Chemistry (Physical Sciences)