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Untiring Pursuit for Glucarate-Based Molecular Imaging Probes by Dongjian Zhang; Qiaomei Jin; Meng Gao; Cuihua Jiang; Yicheng Ni; Jian Zhang is a Medicine article available to read on EtoBox.

What is Untiring Pursuit for Glucarate-Based Molecular Imaging Probes about?

Glucarate, a physiologic end-product of the D-glucuronic acid pathway in mammals, is a six-carbon dicarboxylic acid with a wide range of uses. Glucarate-based molecular imaging probes including [Tc]glucarate and [F]glucarate have been developed and demonstrated to have infarct/necrosis-avid and/or tumor-seeking properties, showing potential applications in early detection of myocardial infarction, evaluation of tissue viability, monitoring of therapeutic effectiveness, and noninvasive imaging of certain tumors including drug-resistant ones. The mechanism by which [Tc]glucarate localizes in acute necrotic tissues has been demonstrated to be largely attributable to its binding to the positively charged histones, which become accessible after the disruption of the cell and nuclear membranes as a result of irreversible damage, while the tumor-seeking mechanism of [Tc]glucarate has been found to be closely related to glucose transporter 5 expression. Moreover, the recently developed [F]glucarate provides a new alternative probe for positron emission tomography imaging and may have potential advantages over [Tc]glucarate. In this review, we present the untiring pursuit for glucarate-base

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Author

Dongjian Zhang; Qiaomei Jin; Meng Gao; Cuihua Jiang; Yicheng Ni; Jian Zhang

Publisher

Springer-Verlag; Springer New York LLC; Elsevier BV; Springer Science and Business Media LLC (ISSN 1536-1632)

Published

2020

Language

EN

Field

Medicine (Health Sciences)