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Interleukin-4 mitigates anxiety-like behavior and loss of neurons and fiber tracts in limbic structures in a microglial PPARγ-dependent manner after traumatic brain injury by Hongjian Pu; Yangfan Wang; Tuo Yang; Rehana K. Leak; R. Anne Stetler; Fang Yu; Wenting Zhang; Yejie Shi; Xiaoming Hu; Ke-jie Yin; T. Kevin Hitchens; C. Edward Dixon; Michael V.L. Bennett; Jun Chen is a Neuroscience article available to read on EtoBox.
What is Interleukin-4 mitigates anxiety-like behavior and loss of neurons and fiber tracts in limbic structures in a microglial PPARγ-dependent manner after traumatic brain injury about?
Traumatic brain injury (TBI) is commonly followed by intractable psychiatric disorders and long-term changes in affect, such as anxiety. The present study sought to investigate the effect of repetitive intranasal delivery of interleukin-4 (IL-4) nanoparticles on affective symptoms after TBI in mice. Adult male C57BL/6 J mice (10–12 weeks of age) were subjected to controlled cortical impact (CCI) and assessed by a battery of neurobehavioral tests up to 35 days after CCI. Neuron numbers were counted in multiple limbic structures, and the integrity of limbic white matter tracts was evaluated using ex vivo diffusion tensor imaging (DTI). As STAT6 is a critical mediator of IL-4-specific transcriptional activation, STAT6 knockout mice were used to explore the role of endogenous IL-4/STAT6 signaling axis in TBI-induced affective disorders. We also employed microglia/macrophage (Mi/Mφ)-specific PPARγ conditional knockout (mKO) mice to test if Mi/Mφ PPARγ critically contributes to IL-4-afforded beneficial effects. We observed anxiety-like behaviors up to 35 days after CCI, and these measures were exacerbated in STAT6 KO mice but mitigated by repetitive IL-4 delivery. We discovered that IL-4
Who reads Interleukin-4 mitigates anxiety-like behavior and loss of neurons and fiber tracts in limbic structures in a microglial PPARγ-dependent manner after traumatic brain injury?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Hongjian Pu; Yangfan Wang; Tuo Yang; Rehana K. Leak; R. Anne Stetler; Fang Yu; Wenting Zhang; Yejie Shi; Xiaoming Hu; Ke-jie Yin; T. Kevin Hitchens; C. Edward Dixon; Michael V.L. Bennett; Jun Chen
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Neuroscience (Life Sciences)