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Development of a Weighted-Incidence Syndromic Combination Antibiogram (WISCA) to guide the choice of the empiric antibiotic treatment for urinary tract infection in paediatric patients: a Bayesian approach by Barbieri, Elisa (author);Bottigliengo, Daniele (author);Tellini, Matteo (author);Minotti, Chiara (author);Marchiori, Mara (author);Cavicchioli, Paola (author);Gregori, Dario (author);Giaquinto, Carlo (author);Da Dalt, Liviana (author);Donà, Daniele (author) is a Medicine article available to read on EtoBox.

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## Background To evaluate the ability of Weighted-Incidence Syndromic Combination Antibiograms (WISCA) to inform the selection of empirical antibiotic regimens for suspected paediatric community-acquired urinary tract infections. ## Methods Data were collected from outpatients (< 15 years) accessing the emergency rooms of Padua University-Hospital and Mestre Dell' Angelo-Hospital (Venice) between January 1st, 2016, and December 31st, 2018. WISCAs were developed by estimating the coverage of eight regimens using a Bayesian hierarchical model adjusted for age, sex, and previous antibiotic treatment or renal/urological comorbidities. ## Results 385 of 620 urine culture requests were included in the model analysis. The most frequently observed bacterium was __E. coli__ (85% and 87%, Centre A and B). No centre effect on coverage estimates was found, and data were successfully pooled together. Coverage ranged from 77.8% (Co-trimoxazole) to 97.6% (Carbapenems). Complex cases and males had significantly lower odds of being covered by a regimen than non-complex cases and females (odds ratio (OR) 0.49 [95% HDI, 0.38–0.65], and OR: 0.73 [95% HDIs, 0.56–0.96] respectively). Children aged 3–5 y

Who reads Development of a Weighted-Incidence Syndromic Combination Antibiogram (WISCA) to guide the choice of the empiric antibiotic treatment for urinary tract infection in paediatric patients: a Bayesian approach?

Author

Barbieri, Elisa (author);Bottigliengo, Daniele (author);Tellini, Matteo (author);Minotti, Chiara (author);Marchiori, Mara (author);Cavicchioli, Paola (author);Gregori, Dario (author);Giaquinto, Carlo (author);Da Dalt, Liviana (author);Donà, Daniele (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)