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Diet-induced dyslipidemia induces metabolic and migratory adaptations in regulatory T cells by Jacob Amersfoort; Frank H Schaftenaar; Hidde Douna; Peter J van Santbrink; Gijs H M van Puijvelde; Bram Slütter; Amanda C Foks; Amy Harms; Estefania Moreno-Gordaliza; Yanyan Wang; Thomas Hankemeier; Ilze Bot; Hongbo Chi; Johan Kuiper is a Medicine article available to read on EtoBox.
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## Abstract ## Aims A hallmark of advanced atherosclerosis is inadequate immunosuppression by regulatory T (Treg) cells inside atherosclerotic lesions. Dyslipidemia has been suggested to alter Treg cell migration by affecting the expression of specific membrane proteins, thereby decreasing Treg cell migration towards atherosclerotic lesions. Besides membrane proteins, cellular metabolism has been shown to be a crucial factor in Treg cell migration. We aimed to determine whether dyslipidemia contributes to altered migration of Treg cells, in part, by affecting cellular metabolism. ## Methods and results Dyslipidemia was induced by feeding __Ldlr__^−/−^ mice a western-type diet for 16–20 weeks and intrinsic changes in Treg cells affecting their migration and metabolism were examined. Dyslipidemia was associated with altered mTORC2 signalling in Treg cells, decreased expression of membrane proteins involved in migration, including CD62L, CCR7, and S1Pr1, and decreased Treg cell migration towards lymph nodes. Furthermore, we discovered that diet-induced dyslipidemia inhibited mTORC1 signalling, induced PPARδ activation and increased fatty acid (FA) oxidation in Treg cells. Moreover, ma
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- Author
- Jacob Amersfoort; Frank H Schaftenaar; Hidde Douna; Peter J van Santbrink; Gijs H M van Puijvelde; Bram Slütter; Amanda C Foks; Amy Harms; Estefania Moreno-Gordaliza; Yanyan Wang; Thomas Hankemeier; Ilze Bot; Hongbo Chi; Johan Kuiper
- Publisher
- Oxford University Press
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)