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Identification of potential microRNAs and KEGG pathways in denervation muscle atrophy based on meta-analysis by Gu, Xinyi (author);Jin, Bo (author);Qi, Zhidan (author);Yin, Xiaofeng (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Identification of potential microRNAs and KEGG pathways in denervation muscle atrophy based on meta-analysis about?
The molecular mechanism of muscle atrophy has been studied a lot, but there is no comprehensive analysis focusing on the denervated muscle atrophy. The gene network that controls the development of denervated muscle atrophy needs further elucidation. We examined differentially expressed genes (DEGs) from five denervated muscle atrophy microarray datasets and predicted microRNAs that target these DEGs. We also included the differentially expressed microRNAs datasets of denervated muscle atrophy in previous studies as background information to identify potential key microRNAs. Finally, we compared denervated muscle atrophy with disuse muscle atrophy caused by other reasons, and obtained the Den-genes which only differentially expressed in denervated muscle atrophy. In this meta-analysis, we obtained 429 up-regulated genes, 525 down-regulated genes and a batch of key microRNAs in denervated muscle atrophy. We found eight important microRNA-mRNA interactions (miR-1/Jun, miR-1/Vegfa, miR-497/Vegfa, miR-23a/Vegfa, miR-206/Vegfa, miR-497/Suclg1, miR-27a/Suclg1, miR-27a/Mapk14). The top five KEGG pathways enriched by Den-genes are Insulin signaling pathway, T cell receptor signaling pathwa
Who reads Identification of potential microRNAs and KEGG pathways in denervation muscle atrophy based on meta-analysis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Gu, Xinyi (author);Jin, Bo (author);Qi, Zhidan (author);Yin, Xiaofeng (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)
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