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Moisture-cured silicone–urethanes—Candidate materials for tissue engineering: A biocompatibility study in vitro by P. Mrówka; J. Kozakiewicz; A. Jurkowska; E. Sienkiewicz; J. Przybylski; Z. Lewandowski; J. Przybylski; M. Lewandowska-Szumieł is a Engineering article available to read on EtoBox.
What is Moisture-cured silicone–urethanes—Candidate materials for tissue engineering: A biocompatibility study in vitro about?
## Abstract This study was performed to verify the response of human bone‐derived cells (HBDCs) to moisture‐cured silicone–urethanes (mcSUUs) __in vitro__, as the first step toward using them as scaffolds for bone tissue engineering. Good surgical handling, tissue cavity filling, stable mechanical properties, and potentially improved oxygen supply to cells after implantation justify the investigation of these nondegradable elastomers. A set of various mcSUUs were obtained by moisture‐curing NCO‐terminated prepolymers, synthesized from oligomeric siloxane diols of two different oligosiloxane chain lengths, and two different diisocyanates (MDI and IPDI), using two different NCO/OH molar ratios. Dibutyltindilaurate (DBTL) or __N__‐dimethylethanolamine (__N__‐met) served as catalysts. After 7 days of culture, cell number, viability, and alkaline phosphatase (ALP) activity were determined, and after 21 days, cell viability and collagen production were determined. Material characteristics significantly influenced the cell response. The mcSUUs prepared with DBTL (widely used in the syntheses of biomaterials) were cytotoxic. The MDI‐based mcSUUs were significantly more favored by HBDCs tha
Who reads Moisture-cured silicone–urethanes—Candidate materials for tissue engineering: A biocompatibility study in vitro?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- P. Mrówka; J. Kozakiewicz; A. Jurkowska; E. Sienkiewicz; J. Przybylski; Z. Lewandowski; J. Przybylski; M. Lewandowska-Szumieł
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)
- Published
- 2010
- Language
- EN
- Field
- Engineering (Physical Sciences)