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Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport by Yan Cao; Jinpeng Lv; Yan Tan; Ruolin Chen; Xiaoxue Jiang; Duo Meng; Kun Zou; Min Pan; Liming Tang is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport about?
Ethnopharmacological relevance: Tribuloside, a natural flavonoid extracted from Chinese medicine Tribulus terrestris L., has shown potent efficacy in treating various diseases. In China, the fruits of Tribulus terrestris L. have long been utilized for relieving headache, dizziness, itchiness, and vitiligo. Water-based extract derived from Tribulus terrestris L. can enhance melanogenesis in mouse hair follicle melanocytes by elevating the expression of α-melanocyte stimulating hormone (α-MSH) and melanocortin-1 recepter (MC-1R). Nevertheless, there is a lack of information regarding the impact of tribuloside on pigmentation in both laboratory settings and living organisms. Aim of the study: The present research aimed to examine the impact of tribuloside on pigmentation, and delve into the underlying mechanism. Materials and methods: Following the administration of tribuloside in human epidermal melanocytes (HEMCs), we utilized microplate reader, Masson-Fontana ammoniacal silver stain, transmission electron microscopy (TEM) and scanning electron microscopy (SEM) to measure melanin contents, dendrite lengths, melanosome counts; L-DOPA oxidation assay to indicate tyrosinase activity, W
Who reads Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Yan Cao; Jinpeng Lv; Yan Tan; Ruolin Chen; Xiaoxue Jiang; Duo Meng; Kun Zou; Min Pan; Liming Tang
- Publisher
- Elsevier BV
- Published
- 2024
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)