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Vaginal misoprostol vs. concentrated oxytocin plus low-dose prostaglandin E2 for second trimester pregnancy termination by John Owen; John C. Hauth is a Medicine article available to read on EtoBox.

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## Objective: To examine the efficacy of vaginal misoprostol for mid-trimester pregnancy termination. ## Methods: This randomized trial compared misoprostol, 200 microg per vaginum q 12 h to a protocol of concentrated oxytocin plus low-dose vaginal prostaglandin e2 suppositories (10 mg q 6 h). success was defined as an induction-to-delivery interval < or =24 h. ## Results: Interim analysis of the first 30 (15-misoprostol, 15-concentrated oxytocin) women demonstrated that the 2 groups were similar with regard to indication for delivery, gestational age, and demographic characteristics. misoprostol was associated with a lower success rate (67 vs. 87%, p = .2), a longer induction-delivery interval (22 h vs. 18 h, p = .09), a higher rate of retained placenta requiring curettage (27 vs. 13%, p = .65), and a higher live birth rate (50 vs. 0%, p = .006). ## Conclusions: Compared to a regimen of concentrated oxytocin plus low-dose prostaglandin e2, misoprostol administered as vaginal tablets in a dose of 200 microg q 12 h is not satisfactory for mid-trimester pregnancy termination in an unselected population.

Who reads Vaginal misoprostol vs. concentrated oxytocin plus low-dose prostaglandin E2 for second trimester pregnancy termination?

Author

John Owen; John C. Hauth

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Parthenon Publishing Group; Wiley (ISSN 1057-0802)

Published

1999

Language

EN

Field

Medicine (Health Sciences)