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Single pass mean residence time in peripheral tissues: A distribution parameter intrinsic to the tissue affinity of a drug by Peter Veng-Pedersen; William R. Gillespie is a Chemistry article available to read on EtoBox.

What is Single pass mean residence time in peripheral tissues: A distribution parameter intrinsic to the tissue affinity of a drug about?

The single pass mean residence time in peripheral tissues, f , , is a characteristic constant of linear pharmacokinetic systems and nonlinear systems with linear distribution kinetics. It is descriptive of distribution kinetics in such systems and is not dependent on elimination kinetics as are other related parameters, e.g., mean residence time in peripheral tissues, $. Equations are derived which permit estimation of bl from experimental data for systems in which no peripheral elimination occurs. The type of data required are systemic drug levels resulting from iv administration. The probability density function for singl\_e pass residence time in peripheral tissues is derived. It is shown that b, is related to the amount of drug in the peripheral tissues at steady state according to (A& = CL,C, b,, where CL, is the distribution-clearance, and C, is the steady-state systemic drug level. Values of bl are presented for

Who reads Single pass mean residence time in peripheral tissues: A distribution parameter intrinsic to the tissue affinity of a drug?

Author

Peter Veng-Pedersen; William R. Gillespie

Publisher

John Wiley and Sons; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-3549)

Published

1986

Language

EN

Field

Chemistry (Physical Sciences)