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Clinical translation for targeting DNA damage repair in non-small cell lung cancer: a review by Xinru Mao; Nung Kion Lee; Shaban Eljali Saad; Isabel Lim Fong is a Medicine article available to read on EtoBox.

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Despite significant advancements in screening, diagnosis, and treatment of non-small cell lung cancer (NSCLC), it remains the primary cause of cancer-related deaths globally. DNA damage is caused by the exposure to exogenous and endogenous factors and the correct functioning of DNA damage repair (DDR) is essential to maintain of normal cell circulation. The presence of genomic instability, which results from defective DDR, is a critical characteristic of cancer. The changes promote the accumulation of mutations, which are implicated in cancer cells, but these may be exploited for anti-cancer therapies. NSCLC has a distinct genomic profile compared to other tumors, making precision medicine essential for targeting actionable gene mutations. Although various treatment options for NSCLC exist including chemotherapy, targeted therapy, and immunotherapy, drug resistance inevitably arises. The identification of deleterious DDR mutations in 49.6% of NSCLC patients has led to the development of novel target therapies that have the potential to improve patient outcomes. Synthetic lethal treatment using poly (ADP-ribose) polymerase (PARP) inhibitors is a breakthrough in biomarker-driven ther

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Author

Xinru Mao; Nung Kion Lee; Shaban Eljali Saad; Isabel Lim Fong

Publisher

AME Publishing Company

Published

2024

Language

EN

Field

Medicine (Health Sciences)