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Study of Radiolabeled Indium‐111 and Yttrium‐90 Ibritumomab Tiuxetan in Primary Central Nervous System Lymphoma by Fabio M. Iwamoto; Jazmin Schwartz; Neeta Pandit‐Taskar; Scott Peak; Chaitanya R. Divgi; Andrew D. Zelenetz; John Humm; Lauren E. Abrey is a Medicine article available to read on EtoBox.

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## Abstract ## BACKGROUND. Therapeutic options for refractory or recurrent primary central nervous system lymphoma (PCNSL) are limited. The blood–brain barrier makes many agents used in systemic lymphomas ineffective in CNS lymphomas. The objective of this study was to determine whether intravenous radioimmunotherapy using anti‐CD20 antibody can be delivered to PCNSL. ## METHODS. This was a single‐institution prospective study. Indium‐111 ibritumomab tiuxetan was used for imaging and dosimetry. Yttrium‐90 ibritumomab tiuxetan at doses of 0.3 to 0.4 mCi/kg were subsequently given for the treatment of recurrent or refractory PCNSL. ^111^In data were used to estimate radiation doses to lesions delivered by ^90^Y ibritumomab tiuxetan therapy. ## RESULTS. Six patients (4 men, 2 women) with a median age of 60 years and median Karnofsky performance status of 70 received both indium‐111 and yttrium‐90 ibritumomab tiuxetan. The median absorbed dose delivered to the CNS lymphoma was 701 cGy compared with 70 cGy to normal brain. The median progression‐free and overall survival times were 6.8 weeks and 14.3 weeks, respectively. ## CONCLUSIONS. The results from this study suggest that it may be

Who reads Study of Radiolabeled Indium‐111 and Yttrium‐90 Ibritumomab Tiuxetan in Primary Central Nervous System Lymphoma?

Author

Fabio M. Iwamoto; Jazmin Schwartz; Neeta Pandit‐Taskar; Scott Peak; Chaitanya R. Divgi; Andrew D. Zelenetz; John Humm; Lauren E. Abrey

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2007

Language

EN

Field

Medicine (Health Sciences)