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Trimethoprim-sulfamethoxazole Therapy for Children With Acute Osteomyelitis by Allison F. Messina; Katie Namtu; Michelle Guild; Juan A. Dumois; David M. Berman is a Medicine article available to read on EtoBox.

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## Background: The emergence of community-acquired methicillin-resistant staphylococcus aureus (ca-mrsa) has complicated the conventional management of osteomyelitis. while oral clindamycin is commonly used to treat acute ca-mrsa osteomyelitis, the emergence of inducible clindamycin resistance among ca-mrsa isolates has made alternative therapy necessary. the excellent oral bioavailability, susceptibility profile, favorable palatability, and low cost of trimethoprim-sulfamethoxazole (tmp-smx) make this drug an attractive option for treating osteomyelitis, yet its clinical efficacy for osteomyelitis has not been established. ## Methods: Between october 1998 and september 2009, 20 children who received a tmp-smx-containing regimen for acute osteomyelitis at all children's hospital were identified from hospital records, and their cases reviewed for clinical outcome and drug safety. ## Results: Patients ranged in age from 9 months to 17 years. twelve (60%) of the patients were male. causative pathogens were found in 8 (40%) cases of which 5 were ca-mrsa and 3 were methicillin-susceptible staphylococcus aureus. eleven patients (55%) received tmp-smx as their primary therapy. the median

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Author

Allison F. Messina; Katie Namtu; Michelle Guild; Juan A. Dumois; David M. Berman

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2011

Language

EN

Field

Medicine (Health Sciences)