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Modulation of lung cancer growth arrest and apoptosis by Phellinus Linteus by Jinjin Guo; Tongbo Zhu; LeaAnn Collins; Zhi-Xiong J. Xiao; Sung-Hoon Kim; Chang-Yan Chen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The __Phellinus__ __Linteus__ (PL) mushroom has been shown to possess anti‐tumor properties. Through influencing lymphocytes, PL indirectly augments the host's immune system against cancer cells. PL has also been demonstrated to reduce tumor proliferation. However, the mechanisms of PL against malignant growth have not yet been fully explored. In this study, we report that PL mediates the following two activities in mouse and human lung cancer cells: cell‐cycle arrest at a low concentration of PL and apoptosis in response to a high dose of PL. After exposure to a low dose of PL, G~1~ growth arrest occurred in the lung cancer cells. The negative growth control mediated by PL is evidenced by the decrease of the activities of cyclin‐dependent kinases CDK2, 4, and 6. In contrast, at high doses, PL‐induced lung cancer cells to undergo apoptosis in a dose‐dependent fashion. This was evidenced by DNA fragmentation, caspase activation, and loss of clonogenecity in the lung cancer cells, all of which were lacking in the lung cancer cells treated with low concentrations of PL as well as the normal mouse lung epithelial cells exposed to either low or high concentrations of PL. The

Who reads Modulation of lung cancer growth arrest and apoptosis by Phellinus Linteus?

Author

Jinjin Guo; Tongbo Zhu; LeaAnn Collins; Zhi-Xiong J. Xiao; Sung-Hoon Kim; Chang-Yan Chen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)

Published

2006

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)