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Opioid use disorder, drug misuse, drug overdose and lack of efficacy: 2 case reports In a case series of three patients, a 31-year-old man and a 43-year-old man were described, who developed opioid use disorder following fentanyl misuse or overdose. Of them, a 31-year-old man exhibited lack of efficacy during treatment with epinephrine and naloxone for opioid use disorder [dosages not stated; not all routes stated].Case 1: A 31-year-old man presented to the Emergency Department during a weekend-long heat wave with body temperature of 97°F. He was found in a parked car with all windows up. On scene, he had cardiac arrest. His cardiac rhythm showed no cardiac activity (asystole). He was treated with naloxone and epinephrine. However, no response was noted (indicating lack of efficacy to naloxone and epinephrine). On examination, he had extensive second-degree burns with sloughing of skin on his left upper extremity and trunk rom contact with the hot interior of the vehicle. An echocardiography confirmed asystole. He was pronounced to death. His mother confirmed that, he had a history of opioid misuse. The toxicology report from the state medical examiner's autopsy resulted positive f

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Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)