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Can I read MAP2K1 Mutations in Advanced Colorectal Cancer Predict Poor Response to Anti-EGFR Therapy and to Vertical Targeting of MAPK Pathway on EtoBox?
MAP2K1 Mutations in Advanced Colorectal Cancer Predict Poor Response to Anti-EGFR Therapy and to Vertical Targeting of MAPK Pathway by Jeremy Chuang; Chongkai Wang; Yuming Guo; Valerie Valenzuela; Jun Wu; Marwan Fakih is a Medicine article available to read on EtoBox.
What is MAP2K1 Mutations in Advanced Colorectal Cancer Predict Poor Response to Anti-EGFR Therapy and to Vertical Targeting of MAPK Pathway about?
## Background: Map2k1 mutations, otherwise known as mek mutations, are rare oncogenic alterations that have been implicated in mapk pathway activation. the impact of map2k1 mutations in colorectal cancer on egfr antibody response has not been characterized. ## Patients and methods: Antitumor activity was assessed in mouse xenograft models with sw48 cell lines harboring map2k1 mutation, and protein expression of the ras signaling pathway was studied by western blot analysis. we retrospectively identified patients with map2k1-mutated metastatic colorectal cancer patients treated at city of hope comprehensive cancer center between 2015 and 2020 using next-generation sequencing. patients' tumor characteristics, treatment response, and outcome are described. additional patients with the map2k1 mutation were identified from the cancer genome atlas and memorial sloan kettering cancer center oncogenomic databases. ## Results: Antitumor activity in mouse xenograft models demonstrated efficacy with combination therapy with egfr and mek inhibition with either braf or erk inhibitors. five patients treated at city of hope between 2015 and 2020 harbored a map2k1 mutation at a frequency of 1%. ap
Who reads MAP2K1 Mutations in Advanced Colorectal Cancer Predict Poor Response to Anti-EGFR Therapy and to Vertical Targeting of MAPK Pathway?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jeremy Chuang; Chongkai Wang; Yuming Guo; Valerie Valenzuela; Jun Wu; Marwan Fakih
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)