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Cisplatin and gemcitabine with either vinorelbine or paclitaxel in the treatment of carcinomas of unknown primary site: Results of an Italian Multicenter, randomized, phase II study by Sergio Palmeri; Vito Lorusso; Laura Palmeri; Marina Vaglica; Camillo Porta; Rolando Nortilli; Francesco Ferraú; Giuseppe Comella; Bruno Massidda; Marco Danova is a Medicine article available to read on EtoBox.

What is Cisplatin and gemcitabine with either vinorelbine or paclitaxel in the treatment of carcinomas of unknown primary site: Results of an Italian Multicenter, randomized, phase II study about?

## Abstract ## BACKGROUND. To date, the standard treatment for patients who have carcinoma of unknown primary site has not been established. ## METHODS. In this randomized Phase II study, 66 previously untreated patients (33 patients per arm) with carcinomas of unknown primary site received cisplatin (35 mg/m^2^) and gemcitabine (1000 mg/m^2^) with either paclitaxel (70 mg/m^2^) or vinorelbine (25 mg/m^2^), and all drugs were administered intravenously on Days 1 and 8 of a 21‐day cycle. Twenty‐nine patients (44%) presented with ≥2 involved sites. The pathologic diagnosis was mainly adenocarcinoma (48 patients; 72.7%) and squamous carcinoma (7 patients; 10.6%). ## RESULTS. In the first arm, 16 patients (48.5%) experienced an objective response, and 9 patients (27.2%) had disease stabilization. In the vinorelbine‐containing arm, 14 patients (42.3%) experienced an objective response, and 8 patients (24.2%) had disease stabilization. The median response duration and the median time to progression were similar in both treatment arms; the median overall survival was 9.6 months (95% confidence interval, 7.11–12.09 months) for patients who received the cisplatin/gemcitabine/paclitaxel regi

Who reads Cisplatin and gemcitabine with either vinorelbine or paclitaxel in the treatment of carcinomas of unknown primary site: Results of an Italian Multicenter, randomized, phase II study?

Author

Sergio Palmeri; Vito Lorusso; Laura Palmeri; Marina Vaglica; Camillo Porta; Rolando Nortilli; Francesco Ferraú; Giuseppe Comella; Bruno Massidda; Marco Danova

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2006

Language

EN

Field

Medicine (Health Sciences)