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Postnatal changes in NMDAR1 subunit expression in the rat trigeminal pathway to barrel field cortex by Rema, V.; Ebner, Ford F. is a Neuroscience article available to read on EtoBox.

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N-methyl-D-aspartate (NMDA) type glutamate receptors are constituted of one obligatory subunit (NRl), expressed as eight splice variants, combined with one or more of four NMDAR2 subunits. Polyclonal antibodies were produced to an N-terminal domain of the NR1 subunit that recognize all eight splice variants. The antibody was used to localize NR1 in the trigeminal pathway to barrel field cortex in rats. The distribution and density of NR1 changes between birth (postnatal day 0 = P-0) and P-360. The trigeminal nuclei already contain a high level of NR1 immunoreactivity on the day of birth. The ventral posterior lateral, ventral posterior medial, and posterior nucleus, medial division, thalamic nuclei show fluctuations in NR1 immunoreactivity levels, starting at birth with moderate densities in neuropil which decrease at P-7, and peak again in neuronal cell bodies as well as the neuropil at P-21. In the cortex, the density of NR1 in layer VI fluctuates with low points at P-7 and P-40. Superficial cortical layers I, 11, and I11 reach adult levels a t P-14 and remain high. NR1 levels decrease sharply in layer IV just prior to P-40 and then slowly recover over the next 3 months to stabil

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Author

Rema, V.; Ebner, Ford F.

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

1996

Language

EN

Field

Neuroscience (Life Sciences)