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Dietary Fructose Promotes Prostate Cancer Growth by Daniela V. Carreño; Néstor B. Corro; Javier F. Cerda-Infante; Carolina E. Echeverría; Catalina A. Asencio-Barría; Verónica A. Torres-Estay; Gonzalo A. Mayorga-Weber; Pablo A. Rojas; Loreto P. Véliz; Pedro A. Cisternas; Viviana P. Montecinos; Ignacio F. San Francisco; Manuel A. Varas-Godoy; Paula C. Sotomayor; Maite A. Castro; Francisco J. Nualart; Nibaldo C. Inestrosa; Alejandro S. Godoy is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Dietary Fructose Promotes Prostate Cancer Growth about?

## Abstract ## Clinical localization of primary tumors and sites of metastasis by PET is based on the enhanced cellular uptake of 2-deoxy-2-[18F]-fluoro-D-glucose (FDG). In prostate cancer, however, PET-FDG imaging has shown limited clinical applicability, suggesting that prostate cancer cells may utilize hexoses other than glucose, such as fructose, as the preferred energy source. Our previous studies suggested that prostate cancer cells overexpress fructose transporters, but not glucose transporters, compared with benign cells. Here, we focused on validating the functional expression of fructose transporters and determining whether fructose can modulate the biology of prostate cancer cells in vitro and in vivo. Fructose transporters, Glut5 and Glut9, were significantly upregulated in clinical specimens of prostate cancer when compared with their benign counterparts. Fructose levels in the serum of patients with prostate cancer were significantly higher than healthy subjects. Functional expression of fructose transporters was confirmed in prostate cancer cell lines. A detailed kinetic characterization indicated that Glut5 represents the main functional contributor in mediating fru

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Author

Daniela V. Carreño; Néstor B. Corro; Javier F. Cerda-Infante; Carolina E. Echeverría; Catalina A. Asencio-Barría; Verónica A. Torres-Estay; Gonzalo A. Mayorga-Weber; Pablo A. Rojas; Loreto P. Véliz; Pedro A. Cisternas; Viviana P. Montecinos; Ignacio F. San Francisco; Manuel A. Varas-Godoy; Paula C. Sotomayor; Maite A. Castro; Francisco J. Nualart; Nibaldo C. Inestrosa; Alejandro S. Godoy

Publisher

American Association for Cancer Research (AACR)

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)