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Electrospun ZnO/Poly(Vinylidene Fluoride-Trifluoroethylene) Scaffolds for Lung Tissue Engineering by Bahareh Azimi; Mohammad Sajad Sorayani Bafqi; Alessandra Fusco; Claudio Ricci; Giuseppe Gallone; Roohollah Bagherzadeh; Giovanna Donnarumma; Mohammed Jasim Uddin; Masoud Latifi; Andrea Lazzeri; Serena Danti is a Medicine article available to read on EtoBox.

What is Electrospun ZnO/Poly(Vinylidene Fluoride-Trifluoroethylene) Scaffolds for Lung Tissue Engineering about?

Due to the morbidity and lethality of pulmonary diseases, new biomaterials and scaffolds are needed to support the regeneration of lung tissues, while ideally providing protective effects against inflammation and microbial aggression. In this study, we investigated the potential of nanocomposites of poly(vinylidene fluoride-co-trifluoroethylene) [P(VDF-TrFE)] incorporating zinc oxide (ZnO), in the form of electrospun fiber meshes for lung tissue engineering. We focused on their anti-inflammatory, antimicrobial and mechanoelectrical character according to different fiber mesh textures (i.e., collected at 500 rpm and 4000 rpm) and compositions: (0/100) and (20/80) w/w% ZnO/P(VDF-TrFE), plain and composite, respectively. The scaffolds were characterized in terms of morphological, physico-chemical, mechanical and piezoelectric properties, as well as biological response of A549 alveolar epithelial cells in presence of lung infecting bacteria. By virtue of ZnO, the composite scaffolds showed a strong anti-inflammatory response in A549 cells, as demonstrated by a significant decrease of interleukin (IL) IL-1α, IL-6 and IL-8 expression in 6 h. In all the scaffold types, but remarkedly in t

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Author

Bahareh Azimi; Mohammad Sajad Sorayani Bafqi; Alessandra Fusco; Claudio Ricci; Giuseppe Gallone; Roohollah Bagherzadeh; Giovanna Donnarumma; Mohammed Jasim Uddin; Masoud Latifi; Andrea Lazzeri; Serena Danti

Publisher

Mary Ann Liebert Inc

Published

2020

Language

EN

Field

Medicine (Health Sciences)