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Can I read miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia on EtoBox?
miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia by Guduric-Fuchs, Jasenka (author);Pedrini, Edoardo (author);Lechner, Judith (author);Chambers, Sarah E.J. (author);O’Neill, Christina L. (author);Mendes Lopes de Melo, Joana (author);Pathak, Varun (author);Church, Rachel H. (author);McKeown, Stuart (author);Bojdo, James (author);Mcloughlin, Kiran J. (author);Stitt, Alan W. (author);Medina, Reinhold J. (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia about?
Hypoxia modulates reparative angiogenesis, which is a tightly regulated pathophysiological process. MicroRNAs (miRNAs) are important regulators of gene expression in hypoxia and angiogenesis. However, we do not yet have a clear understanding of how hypoxia-induced miRNAs fine-tune vasoreparative processes. Here, we identify miR-130a as a mediator of the hypoxic response in human primary endothelial colony-forming cells (ECFCs), a well-characterized subtype of endothelial progenitors. Under hypoxic conditions of 1% O, miR-130a gain-of-function enhances ECFC pro-angiogenic capacity and potentiates their vasoreparative properties . Mechanistically, miR-130a orchestrates upregulation of VEGFR2, activation of STAT3, and accumulation of HIF1α via translational inhibition of . These findings unveil a new role for miR-130a in hypoxia, whereby it activates the VEGFR2/STAT3/HIF1α axis to enhance the vasoregenerative capacity of ECFCs.
Who reads miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Guduric-Fuchs, Jasenka (author);Pedrini, Edoardo (author);Lechner, Judith (author);Chambers, Sarah E.J. (author);O’Neill, Christina L. (author);Mendes Lopes de Melo, Joana (author);Pathak, Varun (author);Church, Rachel H. (author);McKeown, Stuart (author);Bojdo, James (author);Mcloughlin, Kiran J. (author);Stitt, Alan W. (author);Medina, Reinhold J. (author)
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)