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Can I read Synthesis, Kinetic Evaluation and Molecular Docking Studies of Donepezil-based Acetylcholinesterase Inhibitors on EtoBox?
Synthesis, Kinetic Evaluation and Molecular Docking Studies of Donepezil-based Acetylcholinesterase Inhibitors by Makar Makarian; Michael Gonzalez; Stephanie M. Salvador; Shahrokh Lorzadeh; Paula K. Hudson; Stevan Pecic is a Chemistry article available to read on EtoBox.
What is Synthesis, Kinetic Evaluation and Molecular Docking Studies of Donepezil-based Acetylcholinesterase Inhibitors about?
In an effort to develop new therapeutic agents to treat Alzheimer's disease, a series of donepezil-based analogs were designed, synthesized using an environmentally friendly route, and biologically evaluated for their inhibitory activity against electric eel acetylcholinesterase (AChE) enzyme. studies revealed that the phenyl moiety of donepezil can be successfully replaced with a pyridine ring leading to equally potent inhibitors of electric eel AChE. Further kinetic evaluations of the most potent inhibitor showed a dual-binding (mixed inhibition) mode, similar to donepezil. Molecular modeling studies suggest that several additional residues could be involved in the binding of this inhibitor in the human AChE enzyme active site compared to donepezil.
Who reads Synthesis, Kinetic Evaluation and Molecular Docking Studies of Donepezil-based Acetylcholinesterase Inhibitors?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Makar Makarian; Michael Gonzalez; Stephanie M. Salvador; Shahrokh Lorzadeh; Paula K. Hudson; Stevan Pecic
- Published
- 2022
- Language
- EN
- Field
- Chemistry (Physical Sciences)