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International Immunopharmacology, 75 (2019) 105792. doi:10.1016/j.intimp.2019.105792ABSTRACTKeywords:Sepsis is a systemic inflammatory response during infection and remains a major clinical problem with highPlatelet-derived growth factor Bmorbidity and mortality. Platelet-derived growth factor B (PDGF-B) is a member belongs to PDGF family and hasSepsisbeen recently reported higher expressed in survivors of severe sepsis patients. However, the exact role andInflammatory cytokinesunderlying mechanisms of PDGF-BB in sepsis remains unclear. In this study, we found that PDGF-BB levels wereChemokinessignificantly elevated in patients with sepsis, and higher PDGF-BB levels were negatively correlated with thelevels of proinflammatory cytokines (TNF-α, IL-6, IL-1β, IL-8), and chemokines (CXCL-1 and CCL2). PDGF-BBwas also found increased in experimental sepsis in mice. Blockade of PDGF-BB using Tyrphostin AG 1296 aggravated, whereas recombinant PDGF-BB treatment improved survival and tissues injury in both two murinemodels of CLP-induced sepsis and LPS- induced endotoxemia. PDGF-BB blockade increased, whereas PDGF-BBadministration decreased the inflammatory responses, as reflected by proinf

Author

Min Wang & Jilou Wei & Futai Shang & Kui Zang & Ting Ji

Publisher

x

Published

2019

Language

EN