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Photosensitizing Nanoclays for Efficient Cell Uptake and in Vitro Photodynamic Therapy by Malte C. Grüner; Ilaiáli S. Leite; Natalia M. Inada; Andrea S. de Camargo is a Medicine article available to read on EtoBox.

What is Photosensitizing Nanoclays for Efficient Cell Uptake and in Vitro Photodynamic Therapy about?

In this study a straightforward strategy to deliver photosensitizing molecules into cancer cells by using Laponite RD® (LAP) nanodisks as carrier is presented. We report the application of LAP functionalized with a highly hydrophobic Silicon phthalocyanine photosensitizer (SiPc) for efficient cell uptake and photodynamic therapy (PDT) of MCF-7 breast cancer cells in vitro. This inorganic-organic hybrid nanomaterial caused a threefold increase in intracellular ROS levels and 99.7% of cancer cell inactivation after light treatment (630 nm; fluency of 108 J/cm2). With its theranostic capabilities (simultaneous fluorescence and singlet oxygen generation), uptake into cancer cells was monitored to control the photo-inactivation. The functionalized nanodisks already proved to be an efficient photo-inactivator of pathogenic Gram-(+) bacteria and were previously reported as LS10. By extending the use of LS10 to PDT of cancer cells, it is an example of a photosensitizer functionalized nanoclay with multipurpose drug characteristics, demonstrating an intriguing potential for future phototherapeutic studies and applications.

Who reads Photosensitizing Nanoclays for Efficient Cell Uptake and in Vitro Photodynamic Therapy?

Author

Malte C. Grüner; Ilaiáli S. Leite; Natalia M. Inada; Andrea S. de Camargo

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)