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The study investigates the role of c-Cbl in regulating the endocytosis and lysosomal degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) in human airway epithelial cells. c-Cbl facilitates CFTR endocytosis through an adaptor protein mechanism and also ubiquitinates CFTR in early endosomes, promoting its lysosomal degradation. The findings suggest that c-Cbl is crucial for maintaining CFTR levels at the plasma membrane and its proper trafficking within cells.

Author

penber0427

Language

EN