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Can I read Acute Exposure to Pyridostigmine Bromide Disrupts Cholinergic Myenteric Neuroimmune Function in Mice on EtoBox?
Acute Exposure to Pyridostigmine Bromide Disrupts Cholinergic Myenteric Neuroimmune Function in Mice by Claudia A. Collier; Steven Foncerrada; Abigail J. Clevenger; Ashok Shetty; Shreya A. Raghavan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Acute Exposure to Pyridostigmine Bromide Disrupts Cholinergic Myenteric Neuroimmune Function in Mice about?
>50% of Gulf War veterans, who commonly suffer from diarrhea, constipation, and stomach pain, with unclear and understudied pathological causes. During the Persian Gulf War, service personnel was exposed to a wide variety of known and potential health hazards. Chief among them was the prophylactic use of pyridostigmine bromide (PB), to protect military personnel from the potential threat of nerve gas attacks. PB belongs to a class of anti-acetylcholinesterase (AChE) drugs, and some previous works have reported that PB self-administration exposure by deployed service personnel is central to intestinal neuroimmune disruption. However, the sole effect of PB exposure leading to disruptions in intestinal motility is understudied. GI function (digestion, nutrient absorption, and waste excretion) relies on the coordinated operation of discrete cellular compartments within the GI tract. Cells involved span the enteric nervous system (ENS), the musculature (smooth muscle cells (SMCs)), the epithelium, and the immune components. Specific to GI motility, disruptions of which result in FGIDs, the interplay between the ENS and the SMCs of the musculature is paramount. Acetylcholine (ACh) is an
Who reads Acute Exposure to Pyridostigmine Bromide Disrupts Cholinergic Myenteric Neuroimmune Function in Mice?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Claudia A. Collier; Steven Foncerrada; Abigail J. Clevenger; Ashok Shetty; Shreya A. Raghavan
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)