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Two new HLA‐B alleles, B\*4422 and B\*4704, identified in a study of families with autoimmunity by S.E. Grams; P.V. Moonsamy; C. Mano; J.R. Oksenberg; A.B. Begovich is a Immunology and Microbiology article available to read on EtoBox.

What is Two new HLA‐B alleles, B\*4422 and B\*4704, identified in a study of families with autoimmunity about?

**Abstract:** HLA‐B typing of approximately 1 262 individuals from a study of 372 simplex families with multiple sclerosis has led to the identification of two new alleles (HLA‐B\*4422 and HLA‐B\*4704). Sequencing confirmed that both of these new alleles represent novel combinations of previously described sequence motifs, reinforcing the notion that recombination and/or gene conversion‐like events play an important role in generating HLA allelic diversity. The identification of these new alleles brings the total number of HLA‐B alleles to 465.

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Author

S.E. Grams; P.V. Moonsamy; C. Mano; J.R. Oksenberg; A.B. Begovich

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0001-2815)

Published

2002

Language

EN

Field

Immunology and Microbiology (Life Sciences)