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Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing by Atsushi Tamada; Tatsuro Kumada; Yan Zhu; Tomoko Matsumoto; Yumiko Hatanaka; Keiko Muguruma; Zhe Chen; Yasuto Tanabe; Makio Torigoe; Kenta Yamauchi; Hiroshi Oyama; Kazuhiko Nishida; Fujio Murakami is a Neuroscience article available to read on EtoBox.
What is Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing about?
## Background Robo1, Robo2 and Rig-1 (Robo3), members of the Robo protein family, are candidate receptors for the chemorepellents Slit and are known to play a crucial role in commissural axon guidance in the spinal cord. However, their roles at other axial levels remain unknown. Here we examine expression of Robo proteins by cerebellofugal (CF) commissural axons in the rostral hindbrain and investigate their roles in CF axon pathfinding by analysing Robo knockout mice. ## Results We analysed the expression of Robo proteins by CF axons originating from deep cerebellar neurons in rodent embryos, focusing on developmental stages of their midline crossing and post-crossing navigation. At the stage of CF axon midline crossing, mRNAs of Robo1 and Robo2 are expressed in the nuclear transitory zone of the cerebellum, where the primordium of the deep cerebellar nuclei are located, supporting the notion that CF axons express Robo1 and Robo2. Indeed, immunohistochemical analysis of CF axons labelled by electroporation to deep cerebellar nuclei neurons indicates that Robo1 protein, and possibly also Robo2 protein, is expressed by CF axons crossing the midline. However, weak or no expression of
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- Author
- Atsushi Tamada; Tatsuro Kumada; Yan Zhu; Tomoko Matsumoto; Yumiko Hatanaka; Keiko Muguruma; Zhe Chen; Yasuto Tanabe; Makio Torigoe; Kenta Yamauchi; Hiroshi Oyama; Kazuhiko Nishida; Fujio Murakami
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2006-; Springer Science and Business Media LLC (ISSN 1749-8104)
- Published
- 2008
- Language
- EN
- Field
- Neuroscience (Life Sciences)