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Right Atrial Remodeling and Outcome in Patients with Secondary Tricuspid Regurgitation by Michele Tomaselli; Daniela N. Radu; Luigi P. Badano; Francesco P. Perelli; Francesca Heilbron; Andrea Cascella; Mara Gavazzoni; Diana R. Hădăreanu; Sorina Mihaila; Giorgio Oliverio; Marco Penso; Sergio Caravita; Claudia Baratto; Samantha Fisicaro; Gianfranco Parati; Denisa Muraru is a Medicine article available to read on EtoBox.
What is Right Atrial Remodeling and Outcome in Patients with Secondary Tricuspid Regurgitation about?
Background: In patients with secondary tricuspid regurgitation (STR), right atrial remodeling (RAR) is a proven marker of disease progression. However, the prognostic value of RAR, assessed by indexed RA volume (RAVi) and reservoir strain (RAS) remains to be clarified. Accordingly, the aim of our study is to investigate the association with outcome of RAR in patients with STR. ## Methods: We enrolled 397 patients (44% men, 72.7±13 years) with mild to severe STR. Complete twodimensional and speckle-tracking echocardiography analysis of RA and right ventricular (RV) size and function were obtained in all patients. The primary endpoint was the composite of death from any cause and heart failure (HF) hospitalization. ## Results: After a median follow-up of 15 months (IQR: 6-23), the endpoint was reached by 158 patients (39%). Patients with RAS 48 mL/m 2 had significantly lower survival rates compared to patients with RAS ≥13% and RAVi ≤48 mL/m 2 (log rank p<0.001). On multivariable analysis, RAS <13% (HR 2.11; 95% CI, 1.43-3.11; p 48mL/m 2 (HR 1.49; 95% CI, 1.01-2.18; p=0.04) remained associated with the combined endpoint, even after adjusting for RV free-wall longitudinal strain (RV-
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- Author
- Michele Tomaselli; Daniela N. Radu; Luigi P. Badano; Francesco P. Perelli; Francesca Heilbron; Andrea Cascella; Mara Gavazzoni; Diana R. Hădăreanu; Sorina Mihaila; Giorgio Oliverio; Marco Penso; Sergio Caravita; Claudia Baratto; Samantha Fisicaro; Gianfranco Parati; Denisa Muraru
- Publisher
- Elsevier BV
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)