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Mecasermin is primarily used for treating growth hormone insensitivity (Laron syndrome) in children. Pigvisomant is used as a growth hormone receptor antagonist for treating acromegaly. Desmopressin manages esophageal varices by reducing portal pressure through V1 receptor activation, while tolvaptan is approved for autosomal dominant polycystic kidney disease (ADPKD), and somatostatin is used to reduce excessive growth hormone secretion in acromegaly.

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