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Chiral Relay: A Novel Strategy for the Control and Amplification of Enantioselectivity in Chiral Lewis Acid Promoted Reactions by Olivier Corminboeuf; Laura Quaranta; Philippe Renaud; Mei Liu; Craig P. Jasperse; Mukund P. Sibi is a Chemistry article available to read on EtoBox.
What is Chiral Relay: A Novel Strategy for the Control and Amplification of Enantioselectivity in Chiral Lewis Acid Promoted Reactions about?
## Abstract Chiral Lewis acid catalysis has emerged as one of the premiere method to control stereochemistry. Much effort has gone into the design of superior ligands with increasing steric extension to shield distant reactive sites. We report here an alternative and complementary approach based on a “chiral relay”. This strategy focuses on the improved design of achiral templates which may relay and amplify the stereochemistry from ligands. The essence of this strategy is that the chiral Lewis acid would effectively convert an achiral template into a chiral non‐racemic template. This approach combines the advantages of enantioselective catalysis (substoichiometric amount of the chiral inducer) with the ones of chiral auxiliary control (efficient and predictable stereocontrol).
Who reads Chiral Relay: A Novel Strategy for the Control and Amplification of Enantioselectivity in Chiral Lewis Acid Promoted Reactions?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Olivier Corminboeuf; Laura Quaranta; Philippe Renaud; Mei Liu; Craig P. Jasperse; Mukund P. Sibi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0947-6539)
- Published
- 2002
- Language
- EN
- Field
- Chemistry (Physical Sciences)