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Synthesis of Films Based on Chitosan and Protic Ionic Liquids to Be Used as Wound Dressing on the Oral Mucosa by Leonardo Medeiros; Rogério F. dos Santos; Brenda da Rolt Nervis; Marly Jacobi; Lina Naomi Hashizume; Rafaela P. Gazzi; Fernanda Visioli; Júlia Silveira Nunes; Vladimir Lavayen; Vinícius C. De Franco; Tales S. Daitx; Sandra Cerqueira Pereira; Gicelia Antonia Ferreira; Adriana Pohlmann; Silvia Guterres; Luiza Abrahão Frank; Roberta Bussamara is a Materials Science article available to read on EtoBox.

What is Synthesis of Films Based on Chitosan and Protic Ionic Liquids to Be Used as Wound Dressing on the Oral Mucosa about?

## A B S T R A C T Oral mucosal ulcerations expose connective tissue to different pathogens and this can progress to systemic infection. This study aimed to synthesize environmentally-friendly films with chitosan and protic ionic liquids, possessing mucoadhesive properties, activity against opportunistic microorganisms, enhanced malleability and mechanical resistance to be used as a wound dressing on the oral mucosa. Therefore, films with chitosan and 10, 35, and 50 % (wt/wt) of 2-hydroxy diethylammonium lactate, salicylate, and maleate protic ionic liquids were synthesized. Thickness measurements and mechanical properties analysis were performed. In addition, oral mucoadhesion, antimicrobial activity, and cytotoxicity properties were investigated. Results showed that the addition of 35wt% and 50wt% of all kinds of protic ionic liquids tested presented significant improvements in film thickness and mechanical properties. Films based on chitosan and the protic ionic liquid 2-hydroxy diethylammonium salicylate at percentages of 35 and 50wt% exhibited superior mucoadhesive properties, antimicrobial activity on opportunistic microorganisms and an improvement in their flexibility after

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Author

Leonardo Medeiros; Rogério F. dos Santos; Brenda da Rolt Nervis; Marly Jacobi; Lina Naomi Hashizume; Rafaela P. Gazzi; Fernanda Visioli; Júlia Silveira Nunes; Vladimir Lavayen; Vinícius C. De Franco; Tales S. Daitx; Sandra Cerqueira Pereira; Gicelia Antonia Ferreira; Adriana Pohlmann; Silvia Guterres; Luiza Abrahão Frank; Roberta Bussamara

Publisher

Elsevier BV

Published

2023

Field

Materials Science (Physical Sciences)