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What is Synthesis of Heterabicyclo Trifluoroborates about?
The article presents a multigram synthesis method for heterabicyclo[n.1.0]alkan-1-yl trifluoroborates, focusing on two synthetic schemes: lithiation-borylation and regioselective hydroboration. The latter method proved more efficient, yielding up to 50 grams of the target compounds in a single run with an overall yield of 10-41%. This research aims to enhance the availability of these compounds for applications in medicinal chemistry, particularly in C–C coupling reactions.
- Author
- viragm1998
- Language
- EN