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Practical Considerations for the Use of Circulating Tumor DNA in the Treatment of Patients With Cancer: A Narrative Review by Matthew G. Krebs; Umberto Malapelle; Fabrice André; Luis Paz-Ares; Martin Schuler; David M. Thomas; Gilad Vainer; Takayuki Yoshino; Christian Rolfo is a Medicine article available to read on EtoBox.
What is Practical Considerations for the Use of Circulating Tumor DNA in the Treatment of Patients With Cancer: A Narrative Review about?
## Importance Personalized medicine based on tumor profiling and identification of actionable genomic alterations is pivotal in cancer management. Although tissue biopsy is still preferred for diagnosis, liquid biopsy of blood-based tumor analytes, such as circulating tumor DNA, is a rapidly emerging technology for tumor profiling. ## Observations This review presents a practical overview for clinicians and allied health care professionals for selection of the most appropriate liquid biopsy assay, specifically focusing on circulating tumor DNA and how it may affect patient treatment and case management across multiple tumor types. Multiple factors influence the analytical validity, clinical validity, and clinical utility of testing. This review provides recommendations and practical guidance for best practice. Current methodologies include polymerase chain reaction-based approaches and those that use next-generation sequencing (eg, capture-based profiling, whole exome, or genome sequencing). Factors that may influence utility include sensitivity and specificity, quantity of circulating tumor DNA, detection of a small vs a large panel of genes, and clonal hematopoiesis of indetermin
Who reads Practical Considerations for the Use of Circulating Tumor DNA in the Treatment of Patients With Cancer: A Narrative Review?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Matthew G. Krebs; Umberto Malapelle; Fabrice André; Luis Paz-Ares; Martin Schuler; David M. Thomas; Gilad Vainer; Takayuki Yoshino; Christian Rolfo
- Publisher
- American Medical Association (AMA)
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)