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A Targeted and pH-Responsive Nano-Graphene Oxide Nanoparticle Loaded with Doxorubicin for Synergetic Chemo-Photothermal Therapy of Oral Squamous Cell Carcinoma by Ran Li; Chen Liu; Chaoqiong Wan; Tiantian Liu; Rongrong Zhang; Jie Du; Xiangyu Wang; Xiaofeng Jiao; Ruifang Gao; Bing Li is a Materials Science article available to read on EtoBox.

What is A Targeted and pH-Responsive Nano-Graphene Oxide Nanoparticle Loaded with Doxorubicin for Synergetic Chemo-Photothermal Therapy of Oral Squamous Cell Carcinoma about?

## Purpose Oral squamous cell carcinoma (OSCC) is a malignant disease with serious impacts on human health and quality of life worldwide. This disease is traditionally treated through a combination of surgery, radiotherapy, and chemotherapy. However, the efficacy of traditional treatments is hindered by systemic toxicity, limited therapeutic effects, and drug resistance. Fibroblast activation protein (FAP) is a membrane-bound protease. Although FAP has limited expression in normal adult tissues, it is highly expressed in the tumor microenvironment of many solid cancers – a characteristic that makes it an ideal target for anticancer therapy. In this study, we constructed a nano-drug delivery system (NPF@DOX) targeting FAP to increase the therapeutic efficiency of synergistic chemo-photothermal therapy against OSCC. ## Methods We utilized PEGylated nano-graphene oxide (NGO) to link doxorubicin (DOX) and fluorescently-labeled, FAP-targeted peptide chains via hydrogen bonding and π–π bonding to enhance the targeting capability of NPF@DOX. The synthesis of NPF@DOX was analyzed using UV–Vis and FT–IR spectroscopy and its morphology using transmission electron microscopy (TEM). Additional

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Author

Ran Li; Chen Liu; Chaoqiong Wan; Tiantian Liu; Rongrong Zhang; Jie Du; Xiangyu Wang; Xiaofeng Jiao; Ruifang Gao; Bing Li

Publisher

Informa UK Limited

Published

2023

Language

EN

Field

Materials Science (Physical Sciences)