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Enzymatic Kinetic Resolution of Racemic Cyanohydrins via Enantioselective Acylation by Qing Xu; Yongli Xie; Xiaohong Geng; Peiran Chen is a Chemistry article available to read on EtoBox.

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Enzymatic kinetic resolution of a series of aromatic and aliphatic cyanohydrins in organic media has been investigated. The behavior of potential lipases, molecular sieves, acyl reagent, reaction temperature, and organic solvents on the kinetic resolution was studied. The influence of substrate structure, steric, and electronic nature and position of the aryl substituent on the enantioselectivity was discussed. Under the optimized reaction conditions, good enantioselectivity could be achieved for most of the investigated compounds. Specifically, substrates 1a, 1c, 1d, 1f, 1u could be resolved with the kinetic enantiomer ratio (E) higher than 200.

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Author

Qing Xu; Yongli Xie; Xiaohong Geng; Peiran Chen

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4020)

Published

2010

Language

EN

Field

Chemistry (Physical Sciences)