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Synaptic processes and immune-related pathways implicated in Tourette syndrome by Fotis Tsetsos; Dongmei Yu; Jae Hoon Sul; Alden Y. Huang; Cornelia Illmann; Lisa Osiecki; Sabrina M. Darrow; Matthew E. Hirschtritt; Erica Greenberg; Kirsten R. Muller-Vahl; Manfred Stuhrmann; Yves Dion; Guy A. Rouleau; Harald Aschauer; Mara Stamenkovic; Monika Schlögelhofer; Paul Sandor; Cathy L. Barr; Marco A. Grados; Harvey S. Singer; Markus M. Nöthen; Johannes Hebebrand; Anke Hinney; Robert A. King; Thomas V. Fernandez; Csaba Barta; Zsanett Tarnok; Peter Nagy; Christel Depienne; Yulia Worbe; Andreas Hartmann; Cathy L. Budman; Renata Rizzo; Gholson J. Lyon; William M. McMahon; James R. Batterson; Danielle C. Cath; Irene A. Malaty; Michael S. Okun; Cheston Berlin; Douglas W. Woods; Paul C. Lee; Joseph Jankovic; Mary M. Robertson; Donald L. Gilbert; Lawrence W. Brown; Barbara J. Coffey; Andrea Dietrich; Pieter J. Hoekstra; Samuel Kuperman; Samuel H. Zinner; Michael Wagner; James A. Knowles; A. Jeremy Willsey; Jay A. Tischfield; Gary A. Heiman; Nancy J. Cox; Nelson B. Freimer; Benjamin M. Neale; Lea K. Davis; Giovanni Coppola; Carol A. Mathews; Jeremiah M. Scharf; Peristera Paschou; Cathy L. Barr; James R. Batterson; Cheston Berlin; Cathy L. Budman; Danielle C. Cath; Giovanni Coppola; Nancy J. Cox; Sabrina Darrow; Lea K. Davis; Yves Dion; Nelson B. Freimer; Marco A. Grados; Erica Greenberg; Matthew E. Hirschtritt; Alden Y. Huang; Cornelia Illmann; Robert A. King; Roger Kurlan; James F. Leckman; Gholson J. Lyon; Irene A. Malaty; Carol A. Mathews; William M. McMahon; Benjamin M. Neale; Michael S. Okun; Lisa Osiecki; Mary M. Robertson; Guy A. Rouleau; Paul Sandor; Jeremiah M. Scharf; Harvey S. Singer; Jan H. Smit; Jae Hoon Sul; Dongmei Yu; Harald Aschauer Harald Aschauer; Csaba Barta; Cathy L. Budman; Danielle C. Cath; Christel Depienne; Andreas Hartmann; Johannes Hebebrand; Anastasios Konstantinidis; Carol A. Mathews; Kirsten Müller-Vahl; Peter Nagy; Markus M. Nöthen; Peristera Paschou; Renata Rizzo; Guy A. Rouleau; Paul Sandor; Jeremiah M. Scharf; Monika Schlögelhofer; Mara Stamenkovic; Manfred Stuhrmann; Fotis Tsetsos; Zsanett Tarnok; Tomasz Wolanczyk; Yulia Worbe; Lawrence Brown; Keun-Ah Cheon; Barbara J. Coffey; Andrea Dietrich; Thomas V. Fernandez; Blanca Garcia-Delgar; Donald Gilbert; Dorothy E. Grice; Julie Hagstrøm; Tammy Hedderly; Gary A. Heiman; Isobel Heyman; Pieter J. Hoekstra; Chaim Huyser; Young Key Kim; Young-Shin Kim; Robert A. King; Yun-Joo Koh; Sodahm Kook; Samuel Kuperman; Bennett L. Leventhal; Marcos Madruga-Garrido; Pablo Mir; Astrid Morer; Alexander Münchau; Kerstin J. Plessen; Veit Roessner; Eun-Young Shin; Dong-Ho Song; Jungeun Song; Jay A. Tischfield; A. Jeremy Willsey; Samuel Zinner; Harald Aschauer; Cathy L. Barr; Csaba Barta; James R. Batterson; Cheston Berlin; Lawrence Brown; Cathy L. Budman; Danielle C. Cath; Barbara J. Coffey; Giovanni Coppola; Nancy J. Cox; Sabrina Darrow; Lea K. Davis; Christel Depienne; Andrea Dietrich; Yves Dion; Thomas Fernandez; Nelson B. Freimer; Donald Gilbert; Marco A. Grados; Erica Greenberg; Andreas Hartmann; Johannes Hebebrand; Gary Heiman; Matthew E. Hirschtritt; Pieter Hoekstra; Alden Y. Huang; Cornelia Illmann; Joseph Jankovic; Robert A. King; Samuel Kuperman; Paul C. Lee; Gholson J. Lyon; Irene A. Malaty; Carol A. Mathews; William M. McMahon; Kirsten Müller-Vahl; Peter Nagy; Benjamin M. Neale; Markus M. Nöthen; Michael S. Okun; Lisa Osiecki; Peristera Paschou; Renata Rizzo; Mary M. Robertson; Guy A. Rouleau; Paul Sandor; Jeremiah M. Scharf; Monika Schlögelhofer; Harvey S. Singer; Mara Stamenkovic; Manfred Stuhrmann; Jae Hoon Sul; Zsanett Tarnok; Jay Tischfield; Fotis Tsetsos; A. Jeremy Willsey; Douglas Woods; Yulia Worbe; Dongmei Yu; Samuel Zinner; on behalf of the Tourette Association of America International Consortium for Genetics; the Gilles de la Tourette GWAS Replication Initiative; the Tourette International Collaborative Genetics Study; and the Psychiatric Genomics Consortium Tourette Syndrome Working Group is a Neuroscience article available to read on EtoBox.
What is Synaptic processes and immune-related pathways implicated in Tourette syndrome about?
## Abstract Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie the neurobiology of the disorder through genome-wide analysis. We analyzed genome-wide genotypic data of 3581 individuals with TS and 7682 ancestry-matched controls and investigated associations of TS with sets of genes that are expressed in particular cell types and operate in specific neuronal and glial functions. We employed a self-contained, set-based association method (SBA) as well as a competitive gene set method (MAGMA) using individual-level genotype data to perform a comprehensive investigation of the biological background of TS. Our SBA analysis identified three significant gene sets after Bonferroni correction, implicating ligand-gated ion channel signaling, lymphocytic, and cell adhesion and transsynaptic signaling processes. MAGMA analysis further supported the involvement of the cell adhesion and trans-synaptic signaling gene set. The lymphocytic gene set was driven by variants in FLT3, raising an intriguing hypothesis for the involvement of a neuroinflammatory element in TS pat
Who reads Synaptic processes and immune-related pathways implicated in Tourette syndrome?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Fotis Tsetsos; Dongmei Yu; Jae Hoon Sul; Alden Y. Huang; Cornelia Illmann; Lisa Osiecki; Sabrina M. Darrow; Matthew E. Hirschtritt; Erica Greenberg; Kirsten R. Muller-Vahl; Manfred Stuhrmann; Yves Dion; Guy A. Rouleau; Harald Aschauer; Mara Stamenkovic; Monika Schlögelhofer; Paul Sandor; Cathy L. Barr; Marco A. Grados; Harvey S. Singer; Markus M. Nöthen; Johannes Hebebrand; Anke Hinney; Robert A. King; Thomas V. Fernandez; Csaba Barta; Zsanett Tarnok; Peter Nagy; Christel Depienne; Yulia Worbe; Andreas Hartmann; Cathy L. Budman; Renata Rizzo; Gholson J. Lyon; William M. McMahon; James R. Batterson; Danielle C. Cath; Irene A. Malaty; Michael S. Okun; Cheston Berlin; Douglas W. Woods; Paul C. Lee; Joseph Jankovic; Mary M. Robertson; Donald L. Gilbert; Lawrence W. Brown; Barbara J. Coffey; Andrea Dietrich; Pieter J. Hoekstra; Samuel Kuperman; Samuel H. Zinner; Michael Wagner; James A. Knowles; A. Jeremy Willsey; Jay A. Tischfield; Gary A. Heiman; Nancy J. Cox; Nelson B. Freimer; Benjamin M. Neale; Lea K. Davis; Giovanni Coppola; Carol A. Mathews; Jeremiah M. Scharf; Peristera Paschou; Cathy L. Barr; James R. Batterson; Cheston Berlin; Cathy L. Budman; Danielle C. Cath; Giovanni Coppola; Nancy J. Cox; Sabrina Darrow; Lea K. Davis; Yves Dion; Nelson B. Freimer; Marco A. Grados; Erica Greenberg; Matthew E. Hirschtritt; Alden Y. Huang; Cornelia Illmann; Robert A. King; Roger Kurlan; James F. Leckman; Gholson J. Lyon; Irene A. Malaty; Carol A. Mathews; William M. McMahon; Benjamin M. Neale; Michael S. Okun; Lisa Osiecki; Mary M. Robertson; Guy A. Rouleau; Paul Sandor; Jeremiah M. Scharf; Harvey S. Singer; Jan H. Smit; Jae Hoon Sul; Dongmei Yu; Harald Aschauer Harald Aschauer; Csaba Barta; Cathy L. Budman; Danielle C. Cath; Christel Depienne; Andreas Hartmann; Johannes Hebebrand; Anastasios Konstantinidis; Carol A. Mathews; Kirsten Müller-Vahl; Peter Nagy; Markus M. Nöthen; Peristera Paschou; Renata Rizzo; Guy A. Rouleau; Paul Sandor; Jeremiah M. Scharf; Monika Schlögelhofer; Mara Stamenkovic; Manfred Stuhrmann; Fotis Tsetsos; Zsanett Tarnok; Tomasz Wolanczyk; Yulia Worbe; Lawrence Brown; Keun-Ah Cheon; Barbara J. Coffey; Andrea Dietrich; Thomas V. Fernandez; Blanca Garcia-Delgar; Donald Gilbert; Dorothy E. Grice; Julie Hagstrøm; Tammy Hedderly; Gary A. Heiman; Isobel Heyman; Pieter J. Hoekstra; Chaim Huyser; Young Key Kim; Young-Shin Kim; Robert A. King; Yun-Joo Koh; Sodahm Kook; Samuel Kuperman; Bennett L. Leventhal; Marcos Madruga-Garrido; Pablo Mir; Astrid Morer; Alexander Münchau; Kerstin J. Plessen; Veit Roessner; Eun-Young Shin; Dong-Ho Song; Jungeun Song; Jay A. Tischfield; A. Jeremy Willsey; Samuel Zinner; Harald Aschauer; Cathy L. Barr; Csaba Barta; James R. Batterson; Cheston Berlin; Lawrence Brown; Cathy L. Budman; Danielle C. Cath; Barbara J. Coffey; Giovanni Coppola; Nancy J. Cox; Sabrina Darrow; Lea K. Davis; Christel Depienne; Andrea Dietrich; Yves Dion; Thomas Fernandez; Nelson B. Freimer; Donald Gilbert; Marco A. Grados; Erica Greenberg; Andreas Hartmann; Johannes Hebebrand; Gary Heiman; Matthew E. Hirschtritt; Pieter Hoekstra; Alden Y. Huang; Cornelia Illmann; Joseph Jankovic; Robert A. King; Samuel Kuperman; Paul C. Lee; Gholson J. Lyon; Irene A. Malaty; Carol A. Mathews; William M. McMahon; Kirsten Müller-Vahl; Peter Nagy; Benjamin M. Neale; Markus M. Nöthen; Michael S. Okun; Lisa Osiecki; Peristera Paschou; Renata Rizzo; Mary M. Robertson; Guy A. Rouleau; Paul Sandor; Jeremiah M. Scharf; Monika Schlögelhofer; Harvey S. Singer; Mara Stamenkovic; Manfred Stuhrmann; Jae Hoon Sul; Zsanett Tarnok; Jay Tischfield; Fotis Tsetsos; A. Jeremy Willsey; Douglas Woods; Yulia Worbe; Dongmei Yu; Samuel Zinner; on behalf of the Tourette Association of America International Consortium for Genetics; the Gilles de la Tourette GWAS Replication Initiative; the Tourette International Collaborative Genetics Study; and the Psychiatric Genomics Consortium Tourette Syndrome Working Group
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Neuroscience (Life Sciences)