Opening book details…
Can I read Intersession Repeatability of Structural Biomarkers in Early and Intermediate Age-Related Macular Degeneration: A MACUSTAR Study Report on EtoBox?
Intersession Repeatability of Structural Biomarkers in Early and Intermediate Age-Related Macular Degeneration: A MACUSTAR Study Report by Marlene Saßmannshausen; Sarah Thiele; Charlotte Behning; Maximilian Pfau; Matthias Schmid; Sérgio Leal; Ulrich F. O. Luhmann; Robert P. Finger; Frank G. Holz; Steffen Schmitz-Valckenberg; on behalf of the MACUSTAR Consortium is a Medicine article available to read on EtoBox.
What is Intersession Repeatability of Structural Biomarkers in Early and Intermediate Age-Related Macular Degeneration: A MACUSTAR Study Report about?
## Purpose To analyze the intersession repeatability of structural biomarkers in eyes with early and intermediate age-related macular degeneration (iAMD) within the cross-sectional part of the observational multicenter MACUSTAR study. ## Methods Certified site personnel obtained multimodal imaging data at two visits (38 ± 20 [mean ± standard deviation] days apart), including spectral-domain optical coherence tomography (SD-OCT). One junior reader performed systematic and blinded grading at the central reading center, followed by senior reader review. Structural biomarkers included maximum drusen size classification (>63 to ≤125 μm vs. >125 μm), presence of large pigment epithelium detachments (PEDs), reticular pseudodrusen (RPD), vitelliform lesions, and refractile deposits. Intrasession variability was assessed using Cohen's κ statistics. ## Results At the first visit, 202 study eyes of 202 participants were graded as manifesting with either early (__n__ = 34) or intermediate (__n__ = 168) AMD. Grading of imaging data between visits revealed perfect agreement for the maximum drusen size classification (κ = 0.817; 95% confidence interval, 0.70–0.94). In iAMD eyes, perfect to substa
Who reads Intersession Repeatability of Structural Biomarkers in Early and Intermediate Age-Related Macular Degeneration: A MACUSTAR Study Report?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Marlene Saßmannshausen; Sarah Thiele; Charlotte Behning; Maximilian Pfau; Matthias Schmid; Sérgio Leal; Ulrich F. O. Luhmann; Robert P. Finger; Frank G. Holz; Steffen Schmitz-Valckenberg; on behalf of the MACUSTAR Consortium
- Publisher
- Association for Research in Vision and Ophthalmology (ARVO)
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)