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Can I read Recall response to COVID-19 antigen is preserved in people with multiple sclerosis on anti-CD20 medications – A pilot study on EtoBox?
Recall response to COVID-19 antigen is preserved in people with multiple sclerosis on anti-CD20 medications – A pilot study by Tobias Moser; Ferdinand Otto; Ciara O'Sullivan; Wolfgang Hitzl; Georg Pilz; Andrea Harrer; Eugen Trinka; Peter Wipfler is a Medicine article available to read on EtoBox.
What is Recall response to COVID-19 antigen is preserved in people with multiple sclerosis on anti-CD20 medications – A pilot study about?
## Background: Antibody responses to sars-cov-2 vaccination are impaired in people with multiple sclerosis (ms) under anti-cd20 therapies. it is however unclear, whether patients who received the basic immunization prior to anti-b cell medication start respond to the covid-19 booster dose, once b cells are depleted. ## Aim: To investigate the humoral response to recall antigen by covid-19 booster vaccines in people with ms (pwms), who recently started an anti-cd20 therapy compared to people with long-term b cell depletion. ## Methods: We enrolled 15 pwms who had received booster vaccination on anti-cd20 therapy. of these, 11 had established anti-cd20 medications and were therefore vaccinated during a continuous state of b cell depletion (cd20-vaccine cohort). four pwms had received the basic immunization prior to anti-cd20 therapy commencement and only the booster dose (vaccine-cd20-vaccine cohort) under conditions of b cell depletion. we assessed sars-cov-2 specific antibody responses after booster vaccination among both groups and evaluated accompanying b cell numbers and proportions from the peripheral circulation. ## Results: The booster dose of sars-cov-2 vaccination elicited
Who reads Recall response to COVID-19 antigen is preserved in people with multiple sclerosis on anti-CD20 medications – A pilot study?
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- Author
- Tobias Moser; Ferdinand Otto; Ciara O'Sullivan; Wolfgang Hitzl; Georg Pilz; Andrea Harrer; Eugen Trinka; Peter Wipfler
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)