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Can I read Methotrimeprazine versus meperidine and dimenhydrinate in the treatment of severe migraine: A randomized, controlled trial on EtoBox?
Methotrimeprazine versus meperidine and dimenhydrinate in the treatment of severe migraine: A randomized, controlled trial by Ian G Stiell; Daniel G Dufour; David Moher; Margaret Yen; William J Beilby; Norman A Smith is a Medicine article available to read on EtoBox.
What is Methotrimeprazine versus meperidine and dimenhydrinate in the treatment of severe migraine: A randomized, controlled trial about?
Study objective: To compare the effectiveness of IM administration of methotrimeprazine, a non-narcotic, nonaddicting phenothiazine derivative, with that of a combination of rneperidine and dimenhydrinate in the treatment of severe migraine. Design: Double-blind, randomized, controlled trial. Setting: University hospital emergency department. Participants: Consecutive adult patients with migraine who met eligibility criteria. Interventions: Random allocation to receive IM injections of either 37.5 mg methotrimeprazine (Levoprorne ®, Nozinan ®) or 75 mg meperidine (Demerol ®) combined with 50 mg dimenhydrinate (Dramamine ®, Grnvol®). Measurements and main results: The 37 patients in each group who completed the study were similar in all demographic and clinical charncteristics. There were no statistical differences in pain intensity one hour after treatment, change in pain intensity, or pain relief as measured on a visual-analog scale; need for additional analgesia; persistence of nausea or vomiting; adverse effects; or follow-up status, except for prolonged drowsiness, in the group receiving methotrimeprazine. Conclusion: Methotrimeprazine is comparable to meperidine with dimenhydr
Who reads Methotrimeprazine versus meperidine and dimenhydrinate in the treatment of severe migraine: A randomized, controlled trial?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ian G Stiell; Daniel G Dufour; David Moher; Margaret Yen; William J Beilby; Norman A Smith
- Publisher
- Elsevier Science; Elsevier ; Mosby Inc.; Elsevier BV (ISSN 1097-6760)
- Published
- 1991
- Language
- EN
- Field
- Medicine (Health Sciences)