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Reproducibility of Erythrocyte Polyamine Measurements and Correlation with Plasma Micronutrients in an Antioxidant Vitamin Intervention Study by Weiqun Wang; Omer Kucuk; Adrian A. Franke; Lucy Q. Liu; Laurie J. Custer; Carl M. Higuchi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Reproducibility of Erythrocyte Polyamine Measurements and Correlation with Plasma Micronutrients in an Antioxidant Vitamin Intervention Study about?
Erythrocyte polyamine measurements have been previously investigated as candidate biomarkers for hyperproliferation and recently as a potential intermediate endpoint in clinical chemoprevention trials with difluoromethylornithine, an inhibitor of polyamine biosynthesis. This study was performed to determine the reproducibility of erythrocyte polyamine measurements and their possible correlation with plasma micronutrients in seven healthy adults in an antioxidant vitamin intervention study. As part of this cross-over intervention study, three subjects took p-carotene (31.4 mg/day) plus D-a-tocopherol acetate (720 IU/day) supplements during the first 3 months and four subjects took the supplements during the second 3 months. Heparinized blood samples were collected at baseline and every month over total 6 months for simultaneous determination of erythrocyte polyamines and plasma micronutrients by the high-performance liquid chromatographic method. For all the measures of erythrocyte polyamines the intraindividual variation was smaller than that between subjects, and three or four measurements required to accurately characterize long-term erythrocyte polyamines for an individual. The
Who reads Reproducibility of Erythrocyte Polyamine Measurements and Correlation with Plasma Micronutrients in an Antioxidant Vitamin Intervention Study?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Weiqun Wang; Omer Kucuk; Adrian A. Franke; Lucy Q. Liu; Laurie J. Custer; Carl M. Higuchi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)
- Published
- 1996
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)