Can I read Identification of key metabolic pathways reprogrammed by BmNPV in silkworm Bombyx mori on EtoBox?

Identification of key metabolic pathways reprogrammed by BmNPV in silkworm Bombyx mori by Weiwei Zhou; Dandan Song; Han Chen; Qi Tang; Qian Yu; Shuhao Huo; Xiaoyong Liu; Keping Chen; Feifei Zhu is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Identification of key metabolic pathways reprogrammed by BmNPV in silkworm Bombyx mori about?

Elucidating the mechanism of infection of Bombyx mori nuclear polyhedrosis virus (BmNPV) and host antiviral response remains a major scientific task in sericulture. Virus invasion causes a series of antiviral immune responses in the host, and successful infection leads to massive changes in the host's physiological and biochemical state. Current research mainly focuses on silkworm genes and proteins associated with viral infection and resistance, but little is known regarding the host metabolic pathways that the virus utilizes for optimal replication. In this work, key metabolites involved in viral infection were identified, including trehalose, riboflavin, tryptophan, tyrosine, and phenylalanine. The genes associated with metabolite biosynthesis and catabolism were analyzed, and their expression levels were found to be largely consistent with their respective metabolite levels before and after viral treatment in both strains. The screened metabolites were further investigated for their roles in viral replication using exogenous metabolite addition into the culture medium. The results showed that tryptophan effectively inhibited BmNPV replication, while glutamine promoted viral rep

Who reads Identification of key metabolic pathways reprogrammed by BmNPV in silkworm Bombyx mori?

Author

Weiwei Zhou; Dandan Song; Han Chen; Qi Tang; Qian Yu; Shuhao Huo; Xiaoyong Liu; Keping Chen; Feifei Zhu

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)