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What is Spindle Assembly Checkpoint Signalling about?

This review discusses the spindle assembly checkpoint (SAC), which is crucial for ensuring accurate chromosome segregation during cell division by monitoring microtubule-kinetochore interactions. It highlights the mechanisms of SAC signaling, including the formation of the mitotic checkpoint complex (MCC) that inhibits anaphase onset until all chromosomes are properly attached to the spindle. The review also addresses recent advances in understanding SAC dynamics and the implications of SAC defects in cance

Author

sunyearnfan

Language

EN