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Identifying Dysregulated lncRNA-Associated ceRNA Network Biomarkers in CML Based on Dynamical Network Biomarkers by Xu, Junhua; Wu, Min; Sun, Yichen; Zhao, Hongqian; Wang, Yujie; Gao, Jie is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Identifying Dysregulated lncRNA-Associated ceRNA Network Biomarkers in CML Based on Dynamical Network Biomarkers about?

The incidence of chronic myeloid leukemia (CML) is increasing year by year, which is a serious threat to human health. Early diagnosis can reduce mortality and improve prognosis. LncRNAs have been shown to be effective biomarkers for a variety of diseases and can act as competitive endogenous RNA (ceRNA). In this study, the dysregulated lncRNA-associated ceRNA networks (DLCN) of the chronic phase (CP), accelerated phase (AP), and blastic crisis (BC) for CML are constructed. Then, based on dynamic network biomarkers (DNB), some dysregulated lncRNA-associated ceRNA network biomarkers of CP, AP, and BC for CML are identified according to DNB criteria. Thus, a lncRNA (SNHG5) is identified from DLCN\_CP, a lncRNA (DLEU2) is identified from DLCN\_AP, and two lncRNAs (SNHG3, SNHG5) are identified from DLCN\_BC. In addition, the critical index (CI) used to detect disease outbreaks shows that CML occurs in CP, which is consistent with clinical medicine. By analyzing the functions of the identified ceRNA network biomarkers, it has been found that they are effective lncRNA biomarkers directly or indirectly related to CML. The result of this study will help deepen the understanding of CML path

Who reads Identifying Dysregulated lncRNA-Associated ceRNA Network Biomarkers in CML Based on Dynamical Network Biomarkers?

Author

Xu, Junhua; Wu, Min; Sun, Yichen; Zhao, Hongqian; Wang, Yujie; Gao, Jie

Publisher

Hindawi Limited; Hindawi Publishing Corporation (ISSN 2314-6133)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)