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Can I read Activation and inhibition of DNA methyltransferases by S-adenosyl-l-homocysteine analogues on EtoBox?
Activation and inhibition of DNA methyltransferases by S-adenosyl-l-homocysteine analogues by Ritesh Kumar; Richa Srivastava; Ramendra Kumar Singh; Avadhesha Surolia; Desirazu N. Rao is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Activation and inhibition of DNA methyltransferases by S-adenosyl-l-homocysteine analogues about?
The inhibition of methyltransferases is currently of high interest, particularly in the areas of microbial infection and cell proliferation, as there have been serious attempts to develop novel anti-microbial agents. In the present investigation, a series of 11 S-adenosyl-L L-homocysteine analogues have been synthesized and effect of these analogues on DNA methylation catalyzed by DNA methyltransferases was studied. It was found that, while 5 0 -S-(propionic acid)5 0 -deoxy-9-(1 0 -b-D D-ribofuranosyl)1,3-dideazaadenine was an activator of EcoP15I and HhaI DNA methyltransferases, 5 0 -S-(propionic acid)5 0 -deoxy-9-(1 0 -b-dribofuranosyl)adenine inhibited the methyltransferases in a non-competitive manner. An understanding of the binding of analogues to DNA methyltransferases will greatly assist the design of novel anti-microbial compounds.
Who reads Activation and inhibition of DNA methyltransferases by S-adenosyl-l-homocysteine analogues?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ritesh Kumar; Richa Srivastava; Ramendra Kumar Singh; Avadhesha Surolia; Desirazu N. Rao
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)