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Frontal white matter lesions in Alzheimer’s disease are associated with both small vessel disease and AD-associated cortical pathology by Kirsty E. McAleese; Mohi Miah; Sophie Graham; Georgina M. Hadfield; Lauren Walker; Mary Johnson; Sean J. Colloby; Alan J. Thomas; Charles DeCarli; David Koss; Johannes Attems is a Medicine article available to read on EtoBox.
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## Abstract Cerebral white matter lesions (WML) encompass axonal loss and demyelination and are assumed to be associated with small vessel disease (SVD)-related ischaemia. However, our previous study in the parietal lobe white matter revealed that WML in Alzheimer’s disease (AD) are linked with degenerative axonal loss secondary to the deposition of cortical AD pathology. Furthermore, neuroimaging data suggest that pathomechanisms for the development of WML differ between anterior and posterior lobes with AD-associated degenerative mechanism driving posterior white matter disruption, and both AD-associated degenerative and vascular mechanisms contributed to anterior matter disruption. In this pilot study, we used human post-mortem brain tissue to investigate the composition and aetiology of frontal WML from AD and non-demented controls to determine if frontal WML are SVD-associated and to reveal any regional differences in the pathogenesis of WML. Frontal WML tissue sections from 40 human post-mortem brains (AD, n = 19; controls, n = 21) were quantitatively assessed for demyelination, axonal loss, cortical hyperphosphorylated tau (HPτ) and amyloid-beta (Aβ) burden, and arterioloscl
Who reads Frontal white matter lesions in Alzheimer’s disease are associated with both small vessel disease and AD-associated cortical pathology?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Kirsty E. McAleese; Mohi Miah; Sophie Graham; Georgina M. Hadfield; Lauren Walker; Mary Johnson; Sean J. Colloby; Alan J. Thomas; Charles DeCarli; David Koss; Johannes Attems
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Life Sciences)