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Genome Wide CRISPR Screens Identify Critical Targe by Khalander Basha is a document available to read on EtoBox.
Biederstädt et al. conducted genome-wide CRISPR screens in primary human NK cells, identifying MED12, ARIH2, and CCNC as key regulators that enhance CAR-NK cell antitumor activity. The knockout of these genes significantly improved NK cell cytotoxicity, cytokine release, and metabolic fitness, paving the way for more effective NK cell therapies against resistant cancers. This study provides a mechanistic framework for developing next-generation NK cell therapies by targeting identified genetic regulators.
- Author
- Khalander Basha
- Language
- EN