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Antimalarial properties and molecular docking analysis of compounds from Dioscorea bulbifera L. as new antimalarial agent candidates by Chaniad, Prapaporn (author);Mungthin, Mathirut (author);Payaka, Apirak (author);Viriyavejakul, Parnpen (author);Punsawad, Chuchard (author) is a Medicine article available to read on EtoBox.
What is Antimalarial properties and molecular docking analysis of compounds from Dioscorea bulbifera L. as new antimalarial agent candidates about?
## Background At present, the emergence and spread of antimalarial drug resistance has become a significant problem worldwide. There has been a challenge in searching for natural products for the development of novel antimalarial drugs. Therefore, this study aims to evaluate compounds from __Dioscorea bulbifera__ responsible for antimalarial properties and investigate potential interactions of the compounds with __Plasmodium falciparum__ lactate dehydrogenase (__Pf__LDH), an essential glycolytic enzyme in the parasite’s life cycle. ## Methods An in vitro study of antimalarial activity against chloroquine (CQ)-resistant __Plasmodium falciparum__ (K1 strain) and CQ-sensitive __P. falciparum__ (3D7 strain) was performed using the ^3^H-hypoxanthine uptake inhibition method. The cytotoxic effects of the pure compounds were tested against Vero cells using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The interactions of the compounds with the __Pf__LDH active site were additionally investigated using a molecular docking method. ## Results Quercetin (6) exhibited the highest antimalarial activity against the __P. falciparum__ K1 and 3D7 strains, with IC~50~ v
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- Author
- Chaniad, Prapaporn (author);Mungthin, Mathirut (author);Payaka, Apirak (author);Viriyavejakul, Parnpen (author);Punsawad, Chuchard (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)