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Hyperhomocysteinemia and Cardiovascular Risk by contact is a document available to read on EtoBox.
This review proposes a unifying hypothesis on the pathophysiology of hyperhomocysteinemia, suggesting it is a significant risk factor for cardiovascular diseases and neurodegenerative disorders due to its inhibition of catechol-O-methyltransferase (COMT) and subsequent metabolic accumulation of S-adenosyl-L-homocysteine. The paper discusses how elevated levels of catecholamines resulting from this inhibition can lead to cardiovascular dysfunction and chronic damage to vascular endothelial cells. The author
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- EN