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What is Role of Tight Junctions in Cancer Metastasis about?

1) Tight junctions (TJs) play an important role in maintaining the integrity of epithelial cell layers and regulating permeability. They are comprised of transmembrane and intracellular proteins. 2) In cancer, disruptions to TJs can lead to tumor dissociation and metastasis. Low expression of TJ proteins is seen in highly metastatic cancers. 3) The review summarizes current literature on the role of TJs in relation to the tumor microenvironment and how alterations to TJs, such as changes in occludin and c

Author

biancacampitelli

Language

EN